Department of Neurology
Yale School of Medicine
300 George Street
Suite 8300G
New Haven,CT 06511
Office: (203) 737-2765
Lab: (203)737-3514
Fax:(203) 737-2704
Grutzendler Lab
The overall interest  of our laboratory centers around cells in the so called  "neurovascular unit" (neurons, endothelium, astrocytes, pericytes and microglia). We aim at learning about their dynamic properties and how cell-cell interactions are disrupted in vascular and neurodegenerative pathologies. Experiments in the laboratory involve mouse models of various cerebral disorders including microvascular injury and Alzheimer's disease. The majority of projects are imaging-oriented. We use a variety of techniques including transcranial in vivo two photon microscopy, high-resolution confocal and electron microscopy in combination with differential fluorescent cell labeling and genetic/pharmacological  manipulations.
The dynamics and logic of cell-cell
interactions in the neurovascular unit
Yale SCHOOL OF MEDICINE
Copyright © 2010 Jaime Grutzendler. All Rights Reserved